A histiocitose de células de Langerhans é representante de um raro grupo de síndromes histiocitárias, sendo caracterizada pela proliferação das células de Langerhans. Suas manifestações variam de lesão solitária a envolvimento multissistêmico, sendo o acometimento vulvar incomum. Segue-se o relato de caso refratário da doença limitada à pele, em mulher de 57 anos. A paciente apresentava história de pápulas eritematosas ulceradas em couro cabeludo, face, vulva, tronco e axila há seis anos. O diagnóstico da doença é difícil, sendo confirmado neste caso através de estudo imuno-histoquímico e se obteve resposta terapêutica e eficaz, com a administração de talidomida

Langerhans cell histiocytosis is a member of a group of rare histiocytic syndromes and is characterized for the proliferation of histiocytes called Langerhans'cells. Its manifestations vary from a solitary injury to systemic involvement, and vulvar lesions are uncommon. We describe a refractory case of cutaneous limited disease in a 57-year-old woman. She presented with a 6-year history of an erythematous papular eruption of the scalp, face, vulva, trunk and axillae. The diagnosis is difficult and in this case it was confirmed through immunohistochemical study and clinical improvement was achieved with thalidomide

In order to cope with the heterogeneity, autonomy and diversity of interests among the different agents in open multi-agent systems, several governance mechanisms have been defined. Governance mechanism enforce the behavior of agents by establishing a set of norms that describe actions that agents are prohibited, permitted or obligated to do. In this paper we present a governance mechanism that enforces not only dialogical actions but also non-dialogical ones. Although several governance mechanisms have been proposed, none of them satisfactorily deals with non-dialogical actions. Our proposed mechanism is based on testimonies provided by agents about the behavior of other agents. The governance mechanism provides decisions pointing out if norms have been violated or if false testimonies have been supplied. The decisions are based not only on testimonies and depositions provided by the agents but also on the agents’ reputations supplied by a reputation system that is part of the mechanism.

O presente relato descreve um caso de prototecose cutânea causada por Prototheca wickerhamii em uma mulher não imunodeprimida do estado da Bahia, Brasil. Este é o segundo caso descrito no Brasil. O exame dermatológico revelou placas eritematosas infiltradas na superfície flexora do braço e antebraço direitos. Os autores enfatizam os aspectos anatomopatológicos que podem levar a erro diagnóstico. A paciente foi tratada com sucesso com fluconazole.

The present report describes a case of cutaneous protothecosis caused by Prototheca wickerhamii in a non-immunocompromised female from the state of Bahia, Brazil. This is the second case described in Brazil. Dermatological examination revealed diffusely infiltrated erythematous plaques on the flexor aspect of the right arm and forearm. The authors emphasize the pathological aspects that can lead to misdiagnosis this condition. The patient was successfully treated with fluconazole.